Visualizing Pairwise Queries in R

August 2, 2014   

diseasexorg

If you are doing a lot biological research and are interested in identifying whether an association exists between all the pairwise combinations between two sets of terms (e.g. two gene lists), you can use pubmed search results as a proxy for relative association.

In the example below, I show the results from organisms x diseases to give a rough estimate of how much each disease is studied in a given organism. Of course, this should all be taken with a (big) grain of salt because these organisms and diseases have many synonyms or related terms (e.g. M. Musculus is often referred to as Mouse in the literature). Additionally, the result count is based off of whether or not the terms were found together within the title and abstract of the literature only – and not the body of the text in many cases.

Bioinformatics  gist